Yes. For speedy booting it is suggested to use some type of SSD, though an HDD dedicated for the FreeNAS software (ie, not used for data storage) is an option as well. Any USB stick will not handle the number of read-writes and otherwise rather constant use that occurs with FreeNAS. I cannot say what error 13 is though.
My own short experience with FreeNAS reflects similarly, though the metal encapsulated Kingston sticks survived until I wrecked the config they stored, some others did not last long at all due to heat issues I believe or if not heat damage they stopped functioning while too hot *shrugs*.